4383 Medical Drive
Suite 4077
San Antonio, TX
78229
(210) 593-2514
Genomic Profiling Services
Clinical Pathology Consultations
Each patient interaction begins with a Clinical Pathology Consultation in which previous diagnostic test results are reviewed and a plan for Comprehensive Tumor Genome Profiling is created for each individual case.
Therapeutic target evaluation
Genomic profiling of tumors can detect amplifications and deletions of important oncogenes such as HER2, EGFR, and PTEN. Many of these genes are the targets of new therapeutic drugs, and patients may become eligible for clinical trials at the START Center or other locations based on the unique pattern of changes detectable in each patient's tumor. For more information about Phase I trials visit our clinical trials website at www.startthecure.com.
Resolution of equivocal HER2 gene status in breast cancer
Amplification of the HER2 gene on chromosome 17q is associated with a poor prognosis and response to the drug Herceptin®. Standard testing methods yield equivocal or discordant results in many cases making treatment decisions difficult for physicians and patients. The Her17Scan and HerScan tests are alternative methods that use genomic profiling to resolve HER2 gene status as positive or negative for amplification by giving a complete view of chromosome 17.
Leukemia/Lymphoma prognostic markers
Genomic profiling detects clinically relevant prognostic markers in chronic lymphocytic leukemia (CLL) at a higher resolution than existing non-molecular methods giving patients a more personalized diagnosis of their disease. When combined with FISH, this test can also be used for prognosis in acute leukemia, myelodysplastic syndrome, myeloproliferative disorders, and multiple myeloma.
Familial cancer syndrome evaluation
Pediatric tumors such as retinoblastoma and Wilms occur in extended families. Genomic and gene-specific testing for familial risk factors includes testing of the tumor DNA as well as germline genome analysis of the patient and family members.
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